COX-2, MMP-9, and Noguchi Classification Provide Additional Prognostic Information About Adenocarcinoma of the Lung
| Autor: | Carolina Michelin, A. L. Garippo, Lea M.M. Demarchi, A.J.F.C. Lichtenfels, Nise Hitomi Yamaguchi, T Y Takagaki, Tatiana Moya, Vera Luiza Capelozzi, Paulo Hilário Nascimento Saldiva, Alecsander Guillaumon Pereira da Silva, Robin T. Vollmer, Pedro M. Azevedo, Venancio Alves |
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| Rok vydání: | 2004 |
| Předmět: |
Pathology
medicine.medical_specialty biology business.industry Proportional hazards model medicine.medical_treatment General Medicine Matrix metalloproteinase medicine.disease Staining Cytoplasmic staining biology.protein Adenocarcinoma of the lung medicine Immunohistochemistry Cyclooxygenase business Adjuvant |
| Zdroj: | American Journal of Clinical Pathology. 121:78-86 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/p2cdfgu1u7clv5yr |
| Popis: | We report immunohistochemical staining results for cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 in primary tumors of 117 patients with resected adenocarcinoma of the lung (median follow-up, 20 months). For COX-2, we graded the degree of tumor staining according to the sum of staining intensity and the proportion of cells staining. For MMP-9, we used morphometry to quantify cytoplasmic staining. We used the Cox proportional hazards model to analyze overall survival. With only 29 patients censored at last follow-up, after controlling for the effect of pathologic stage, staining for COX-2 and MMP-9 and subtype of tumor were related significantly to survival ( P < 6 × 10−5). The effects of COX-2 and MMP-9 were opposite. Whereas any staining for COX-2 decreased the hazard and increased survival time, increased staining for MMP-9 increased the hazard and decreased survival time. The results also suggested that staining for COX-2 decreases with dedifferentiation. Our results suggest that staining for the combination of COX-2 and MMP-9 and categorizing tumors into papillary and nonpapillary types may provide important prognostic information for patients with resected adenocarcinoma of the lung; it is possible that these 3 variables could aid decisions about postoperative adjuvant treatment. |
| Databáze: | OpenAIRE |
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