Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT3 Receptor Antagonists in Mice
Autor: | Jean-Marie Gillardin, Philippe Girard, Yannick Pansart, Marie-Claude Coppé, Betty Niedergang |
---|---|
Rok vydání: | 2009 |
Předmět: | |
Zdroj: | Pharmacology. 83:243-246 |
ISSN: | 1423-0313 0031-7012 |
Popis: | Background/Aims: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT3 receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). Methods: The present study was designed to explore the effect of 3 serotonin 5-HT3 receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. Results: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. Conclusion: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery. |
Databáze: | OpenAIRE |
Externí odkaz: |