Modulation of Paracetamol and Nefopam Antinociception by Serotonin 5-HT3 Receptor Antagonists in Mice

Autor:	Jean-Marie Gillardin, Philippe Girard, Yannick Pansart, Marie-Claude Coppé, Betty Niedergang
Rok vydání:	2009
Předmět:	Pharmacology biology Nausea business.industry General Medicine 5-HT3 receptor Nefopam Nociception biology.protein Vomiting medicine Serotonin medicine.symptom Receptor Adverse effect business medicine.drug
Zdroj:	Pharmacology. 83:243-246
ISSN:	1423-0313 0031-7012
Popis:	Background/Aims: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT3 receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol). Methods: The present study was designed to explore the effect of 3 serotonin 5-HT3 receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests. Results: Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test. Conclusion: These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::368f294b78af10f429e4868847ec9d67 https://doi.org/10.1159/000207448 Zobrazit plný text záznamu