Anogenital Distance, a Biomarker of Prenatal Androgen Exposure Is Associated With Prostate Cancer Severity
| Autor: | Francisco Martínez-Díaz, Julián Oñate-Celdrán, Jaime Mendiola, Damián García-Escudero, Alberto M. Torres-Cantero, Ana B Maldonado-Cárceles, Eva M. Vera-Porras, Carlos Sánchez-Rodríguez, Julián J. Arense-Gonzalo, Paula Samper-Mateo, Marcos Torres-Roca |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
030219 obstetrics & reproductive medicine medicine.diagnostic_test medicine.drug_class business.industry Urology Anogenital distance Nomogram urologic and male genital diseases Anus Androgen medicine.disease 03 medical and health sciences Prostate cancer 0302 clinical medicine medicine.anatomical_structure Oncology Prostate 030220 oncology & carcinogenesis Biopsy medicine Biomarker (medicine) business |
| Zdroj: | The Prostate. 77:406-411 |
| ISSN: | 0270-4137 |
| DOI: | 10.1002/pros.23279 |
| Popis: | Background Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Experimental studies have shown that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The aim of this study is to assess the relationship between anogenital distance (AGD), as an indirect marker of prenatal hormonal environment, and prostate cancer (PCa) severity. Materials We conducted a cross-sectional study with a total of 120 PCa patients with confirmed biopsy of the tumour from April 2007 to July 2015. Two variants of the anogenital distance were assessed, from the anus to the posterior base of the scrotum (AGDAS ) and to the cephalad insertion of the penis (AGDAP ). We compared differences in groups to evaluate the association between AGD measurements and severity of the preoperative biopsy and clinical scores. Results Longer AGDAS was significantly associated with the highest Gleason score (P = 0.015) and D'Amico nomogram (P = 0.048). In contrast, no statistical differences were found in the AGDAP and severity of the preoperative biopsy. Conclusions These findings are consistent with the hypothesis that a higher prenatal androgen exposure is associated with higher severity of PCa. Prostate 77: 406-411, 2017. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text