| Autor: |
Anatol Fritsch, Arghyadip Mukherjee, Ben T. Larson, Nicolas T. Chartier, Stephann W Grill, Julia Pfanzelter, Moritz Kreysing, Frank Jülicher, Sebastian Früthauer |
| Rok vydání: |
2020 |
| Předmět: |
|
| Popis: |
Oocytes are large and resourceful. During oogenesis some germ cells grow, typically at the expense of others that undergo apoptosis. How germ cells are selected to live or die out of a homogeneous population remains unclear. Here we show that this cell fate decision inC. elegansis mechanical and related to tissue hydraulics. Germ cells become inflated when the pressure inside them is lower than in the common cytoplasmic pool. This condition triggers a hydraulic instability which amplifies volume differences and causes some germ cells to grow and others to shrink. Shrinking germ cells are extruded and die, as we demonstrate by reducing germ cell volumes via thermoviscous pumping. Together, this reveals a robust mechanism of mechanochemical cell fate decision making in the germline. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
