Nanoparticle-Sensitized Photodegradation of Bilirubin and Potential Therapeutic Application
| Autor: | Abhinandan Makhal, Mohammad Abbas Mahmood, Samir Kumar Pal, Sunandan Baruah, Soumik Sarkar, Joydeep Dutta |
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| Rok vydání: | 2012 |
| Předmět: |
Antioxidant
Chemistry medicine.medical_treatment Kinetics Wide-bandgap semiconductor Nanoparticle Nanotechnology Photochemistry Nanomaterial-based catalyst Surfaces Coatings and Films Electronic Optical and Magnetic Materials Catalysis General Energy medicine Degradation (geology) Physical and Theoretical Chemistry Photodegradation |
| Zdroj: | The Journal of Physical Chemistry C. 116:9608-9615 |
| ISSN: | 1932-7455 1932-7447 |
| DOI: | 10.1021/jp301316e |
| Popis: | Bilirubin (BR) is a protective antioxidant; however, when its conjugation and excretion are impaired, as in neonatal and hereditary jaundice, BR accumulates and may cause severe neurotoxicity. Here, we report a novel mechanism for ZnO nanoparticle (NP)-sensitized BR degradation via defect-mediated nonradiative energy transfer pathway. Among different sizes and shapes, ZnO particles with diameter of 5 nm having very high concentration of defect states are found to be the most effective catalyst, which particularly follows a pseudofirst-order kinetics validating the Langmuir–Hinshelwood model of surface catalysis. The nontoxic wide band gap ZnO NPs essentially transmit defect-mediated visible optical radiation, which is not supposed to interfere with the conventional phototherapy process. Therefore, the recyclable ZnO nanocatalysts essentially invite an added advantage in potential therapeutic applications and/or in a flow-device that has been explored in the present study. |
| Databáze: | OpenAIRE |
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