| Autor: |
Xujuan Huang, Zhenqing Ding, Zhaosheng Cai, Ting Wang, Xinxin Yang, Shibin Shang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BioResources. 17:4331-4346 |
| ISSN: |
1930-2126 |
| DOI: |
10.15376/biores.17.3.4331-4346 |
| Popis: |
Dehydroabietol polyoxyethylene(10) ether (DHA(EO)10H) was reacted with epichlorohydrin (ECH) using BF3 as catalyst and transformed into DHA(EO)10H-ECH, then dehydrochlorinated in the presence of sodium hydroxide and converted into dehydroabietyl polyoxyethylene(10) glycidyl ether (DHA(EO)10GE). Hydroxyethyl chitosan (HEC) was modified with DHA(EO)10GE, and a series of different DHA(EO)10GE-grafted HECs (DHA(EO)10GE-g-HECs) were prepared. Finally, the hydrogels based on DHA(EO)10GE-g-HECs were obtained through the reaction between genipin (GE) and DHA(EO)10GE-g-HECs. Effects of the grafting degree (DG) of DHA(EO)10GE and the dosage of GE on the gelation ability of mixed solution composed of DHA(EO)10GE-g-HECs and GE were investigated, and the behaviors of DHA(EO)10GE-g-HEC/GE hydrogels as carriers for loading chloramphenicol (CAP) were studied. It was found that the gelling time of the DHA(EO)10GE-g-HEC with high DG was longer than that with low DG, and a higher GE dosage could improve the capability of DHA(EO)10GE-g-HEC to form hydrogels. The relation between the cumulative release rate of CAP, which was loaded in DHA(EO)10GE-g-HEC/GE gel, and the release times in artificial intestinal fluid could be well described by Boltzmann function. Increasing the DG or decreasing the GE dosage could improve the final cumulative release. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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