Chitosan/Clotrimazole microcapsules forTinea pedistreatment:in-vitroantifungal and cytotoxicity study
| Autor: | Chi Wai Kan, Joanne Yip, Kelvin Cheuk, Hing-Cheong Cheung, S. Y. Cheng, Chun-Wah Marcus Yuen, Hang-Mei Polly Leung, Liwei Liu |
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| Rok vydání: | 2014 |
| Předmět: |
Antifungal
Coacervate Materials science Polymers and Plastics biology medicine.drug_class Clotrimazole Materials Science (miscellaneous) Trichophyton rubrum biology.organism_classification Industrial and Manufacturing Engineering In vitro Chitosan chemistry.chemical_compound chemistry Skin cell medicine General Agricultural and Biological Sciences Cytotoxicity Nuclear chemistry Biomedical engineering medicine.drug |
| Zdroj: | The Journal of The Textile Institute. 106:641-647 |
| ISSN: | 1754-2340 0040-5000 |
| Popis: | To derive a form of treatment for Tinea pedis (also known as athlete’s foot), an attempt has been made to synthesize chitosan microcapsules that contain an antifungal agent using a coacervation technique. The antifungal agent, namely, clotrimazole, is encapsulated in different amounts: 25, 50, 75, and 100 mg. Optical and scanning electron microscopies demonstrate that the newly developed microcapsules have spherical core–shell forms with smooth surfaces and the particle sizes range from 2 to 10 μm. It is observed that chitosan microcapsules with a drug input of 25 mg clotrimazole show the highest encapsulation efficiency when compared with microcapsules that have 50, 75, and 100 mg of drug input. An analysis of the in vitro antifungal activity confirms that the chitosan/clotrimazole microcapsules show obvious inhibition of Trichophyton rubrum growth. The cytotoxicity results show that the newly developed microcapsules are non-cytotoxic to skin cell lines. The prepared drug-loaded microcapsules could be ap... |
| Databáze: | OpenAIRE |
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