Synthesis and Characterization of Related Substances of Deferasirox, an Iron (Fe3+) Chelating Agent

Autor:	Vascuri Janardhana Rao, P. Badrinadh Gupta, Aminul Islam, Kagga Mukkanti, N. A. Vekariya
Rok vydání:	2012
Předmět:	Iron Chelating Process development Organic Chemistry Deferasirox Ethyl ester chemistry.chemical_compound Orally active chemistry medicine Organic chemistry Chelation Imide Derivative (chemistry) Nuclear chemistry medicine.drug
Zdroj:	Synthetic Communications. 42:3200-3210
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397911.2011.580068
Popis:	Deferasirox is an orally active iron chelating agent, and during process development for deferasirox, we observed six related substances (impurities), namely deferasirox methyl ester, deferasirox salicylyl derivative, deferasirox ethyl ester, deferasirox methoxy carbonyl derivative, bis(salicyl)imide, and deferasirox-2-isomer. The present work describes the detection, origin, synthesis, and characterization of these related substances.
Databáze:	OpenAIRE
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