Copper complexes: cytotoxicity and transport possibilities
| Autor: | A. P. Orlov, Tatiana P. Trofimova, A. S. Borodkov, Alexander A. Yaroslavov, Alexey N. Proshin, N. S. Zolotova, V. V. Spiridonov, I. A. Ivanov, Marina A. Orlova |
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| Rok vydání: | 2019 |
| Předmět: |
Copper complex
medicine.diagnostic_test 010405 organic chemistry chemistry.chemical_element General Chemistry 010402 general chemistry Mass spectrometry 01 natural sciences Copper Jurkat cells 0104 chemical sciences Flow cytometry chemistry.chemical_compound chemistry Elemental analysis medicine Benzamide Cytotoxicity Nuclear chemistry |
| Zdroj: | Russian Chemical Bulletin. 68:1933-1939 |
| ISSN: | 1573-9171 1066-5285 |
| DOI: | 10.1007/s11172-019-2649-2 |
| Popis: | A copper complex with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide was synthesized for the first time and characterized by 1H NMR spectroscopy, LETDY mass spectrometry, and elemental analysis. A comparative study of the obtained complex and copper 2-aminopyrimidine complex was performed by flow cytometry on normal lymphocytes and Jurkat cells. Complexes with radionuclides 64,67Cu (with and wihout a carrier) were prepared, and distribution of the labeled complexes in the organs of mice was considered. Packing in carboxymethylcellulose-based microgels was proposed as a transport form for the complexes. The results show a promise of the obtained materials as potential radiopharmaceutical agents. |
| Databáze: | OpenAIRE |
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