Synthesis, Characterization, Crystal Structure and Biological Study of Carboxamides Obtained from 2-Aminothiazole Derivatives
| Autor: | Anita R. Banpurkar, Franc Perdih, Sachin S. Wazalwar |
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| Rok vydání: | 2019 |
| Předmět: |
biology
Chemistry Biological activity General Chemistry Crystal structure 010402 general chemistry 010403 inorganic & nuclear chemistry Condensed Matter Physics biology.organism_classification 01 natural sciences 0104 chemical sciences Solvent Crystallography chemistry.chemical_compound Yield (chemistry) Organic chemistry Candida albicans Antibacterial activity Aspergillus clavatus Organometallic chemistry |
| Zdroj: | Journal of Chemical Crystallography. 50:319-329 |
| ISSN: | 1572-8854 1074-1542 |
| Popis: | Two series of novel thiazolylcarboxamide derivatives were synthesized by the reaction of ethyl 2-amino-4-methylthiazole-5-carboxylate or 1-(2-amino-4-methylthiazol-5-yl)ethan-1-one with four substituted carbonyl chlorides at 0 °C in excellent yield. All products were characterized by FTIR, 1H NMR spectroscopy and mass spectrometry. Crystal structures of four compounds were studied by X-ray analysis. All the synthesized compounds were screened against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes for antibacterial activity and against Candida albicans, Aspergillusniger and Aspergillus clavatus for antifungal activity. Present study describes the biological activity and crystal structure study of carboxamides obtained from 2-aminothaizol derivatives. Owing to the insolubility of these amides in single volatile solvent, crystals were grown in a mixture of solvents. |
| Databáze: | OpenAIRE |
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