Quantification of carcinoembryonic antigen-like activities in normal human gastrointestinal secretions
| Autor: | H V Ammon, Karl H. Holtermuller, Vay Liang W. Go, Sidney F. Phillips, Einar Krag |
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| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Gastrointestinal tract medicine.medical_specialty endocrine system diseases biology business.industry Secretory Rate Stomach Ileum Gastroenterology digestive system diseases Jejunum medicine.anatomical_structure Carcinoembryonic antigen Oncology Internal medicine medicine biology.protein Duodenum Secretion business neoplasms |
| Zdroj: | Cancer. 36:2346-2350 |
| ISSN: | 1097-0142 0008-543X |
| Popis: | The secretion of carcinoembryonic antigen-like (CEA-like) material into the gastrointestinal tract of 28 fasting normal men was quantified by using intestinal perfusion techniques. CEA-like material was recovered from all levels of the gastrointestinal tract. The highest secretory rate was in the colon (mean +/- SE, 2.41 +/- 2.0 mug/minute per colon), followed by pancreatobiliary secretion and pancreatic secretion. The secretory rate from the stomach, duodenum, jejunum, and ileum was less than 20 ng/minute. After perchloric acid extraction, the CEA-like material from the colon had the same chromatographic and radioimmunologic properties as [125I] CEA. These data suggest that the CEA-like material is normally secreted into the gastrointestinal tract and particularly into the colon. |
| Databáze: | OpenAIRE |
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