Synthesis of Chromeno[3,4-c]pyridines by Rhodium(III)-Catalyzed Annulation of Coumarinyl Ketoxime Esters and Alkynes

Autor:	Cui-Hong Lu, Wei-Dong Liu, Zhi-Wei Li, Xie Xinyun, Jiang-Sheng Li, Yang Panpan, Si Jiang, Qian Yang
Rok vydání:	2019
Předmět:	Annulation 010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Rhodium Catalysis chemistry.chemical_compound chemistry Drug Discovery Pyridine
Zdroj:	Tetrahedron. 75:4602-4610
ISSN:	0040-4020
Popis:	An efficient, scalable synthetic method of chromeno[3,4-c]pyridine scaffolds through redox-neutral [4 + 2] annulation between coumarinyl ketoxime esters and internal alkynes has been developed using the rhodium(III) catalytic system. The present transformation proceeds under mild conditions, features good functional group compatibility and obivates the use of external oxidants. Ready access to pyridine derivatives bearing three carbon substituents is exemplified.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::363b1c934235b99aec358e39fa2a80ae https://doi.org/10.1016/j.tet.2019.07.002 Zobrazit plný text záznamu Full Text from ScienceDirect