Biosynthesis of L-valine in Salmonella typhimurium: origin of the diastereotopic methyl groups

Autor:	Frank B. Armstrong, Charles J. R. Hedgecock, Elizabeth L. Lipscomb, David H. G. Crout
Rok vydání:	1980
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Salmonella Enzyme chemistry Biosynthesis Valine Stereochemistry medicine Molecular Medicine Trigonal crystal system medicine.disease_cause Methyl group
Zdroj:	Journal of the Chemical Society, Chemical Communications. :304
ISSN:	0022-4936
DOI:	10.1039/c39800000304
Popis:	When [1,3,5-13C3]-α-acetolactate {[1,3,5-13C3]-2-hydroxy-2-methyl-3-oxobutanoate}(1′) was incubated with a cell-free system from Salmonella typhimurium, the valine (5′) produced was labelled in the C-4 pro-S position, proving that during the tertiary ketol rearrangement catalysed by the enzyme reductoisomerase, the methyl group transfer is to the re face of the trigonal centre at C-3 of α-acetolactate (1′).
Databáze:	OpenAIRE
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