Metabolomic Analysis Reveals the Adaptation in the P. przewalskii to Se-Deprived Environment
| Autor: | Qionglian Zhang, Xiaoyun Shen, Kui Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Bile acid biosynthesis
biology Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry chemistry.chemical_element General Medicine biology.organism_classification Biochemistry Procapra przewalskii Inorganic Chemistry chemistry.chemical_compound Metabolomics chemistry Downregulation and upregulation Biosynthesis Pyrimidine metabolism Adaptation Selenium |
| Zdroj: | Biological Trace Element Research. 200:3608-3620 |
| ISSN: | 1559-0720 0163-4984 |
| DOI: | 10.1007/s12011-021-02971-0 |
| Popis: | The Procapra przewalskii inhabits in a selenium (Se)-deprived environment in long-term, but they have no pathological manifestations due to the Se deprivation. This study aimed to reveal the underlying adaptation induced by Se deprivation. In the analysis, a total of 93 significantly changed metabolites were identified in positive and negative ion modes, including 46 upregulated and 47 downregulated compounds in the Se-deprived group. The differential metabolites were annotated as the major molecules in bile acid biosynthesis, biosynthesis of unsaturated fatty acids, and pyrimidine metabolism, respectively. This study systematically analyzed the serum metabolomics characteristics of P. przewalskii under Se-deprived conditions for the first time, providing a basis for further understanding of the metabolic mechanism of P. przewalskii in the Se-deprived environment. |
| Databáze: | OpenAIRE |
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