190-OR: Weight-Loss after Exercise Increases Non-Insulin-Dependent Glucose Clearance in Adults with Metabolic Syndrome
| Autor: | John P. Kirwan, Adithya Hari, Christopher L. Axelrod, Jacob T. Mey |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Glucose Clearance
medicine.medical_specialty Adiponectin business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Stimulation medicine.disease Endocrinology Insulin resistance Basal (medicine) Weight loss Internal medicine Internal Medicine medicine Metabolic syndrome medicine.symptom business |
| Zdroj: | Diabetes. 68 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db19-190-or |
| Popis: | Fasting plasma glucose is a composite measure of hepatic glucose production (HGP) and non-insulin-dependent (basal) tissue glucose clearance rate (bGCR). A rise in fasting plasma glucose, within the nondiabetic range, is purported to be regulated by decreased bGCR rather than increased HGP. However, the role of bGCR in improving metabolic syndrome (MetS) is not yet fully understood. We sought to explore the novel impact of weight loss induced by exercise on bGCR in individuals with MetS. Fourteen sedentary adults with MetS (9 females, 68 years, 35.2 kg/m2) participated in a 12-week moderate intensity exercise program (~65% VO2max, 1 hr/day, 5 days/week). MetS was defined using ATP III guidelines. Insulin resistance (IR) was estimated using a hyperinsulinemic (40 mU/m2/min) euglycemic (90 mg/dL) clamp. Rate of glucose disappearance (Rd) was determined using [6,6-2H2]-glucose during fasting and insulin stimulation. GCR was calculated as Rd relative to the prevailing glucose concentration. At baseline, bGCR correlated with IR and adiponectin (r=0.69 and 0.68, P Disclosure A. Hari: None. C.L. Axelrod: None. J.T. Mey: None. J.P. Kirwan: None. Funding National Institutes of Health; National Center for Research Resources |
| Databáze: | OpenAIRE |
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