| Autor: |
Monika Dwivedi, Neelu Singh, Jovita Kanoujia, I. S. Singh, Shubhini A. Saraf, Poonam Parashar, Abhishek Yadav, Shalini Gautam |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-592061/v1 |
| Popis: |
The present investigation deals with solubility enhancement of Etodolac (ETD) through co-crystals technique utilizing various co-formers and to evaluate their therapeutic efficacy against carrageenan-induced inflammation. Co-formers citric acid anhydrous and tartaric acid were selected to formulate ETD co-crystals to improve solubility and dissolution employing neat grinding technique. The prepared co-crystals were characterized for solubility enhancement, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro dissolution and stability studies. The co-crystals were further investigated for in vivo studies to assess their potential to cure paw edema in mice. The outcome of the study illustrated significantly improved solubility and dissolution of ETD up to 6.15 folds using citric acid. Approximately a two-fold reduction in nitric oxide and cytokines levels was observed with optimized formulation. Also, substantial inhibition of inflammation was observed in paw edema induced animals. In sight of the above results the co-crystal approach could be an alternative for enhanced therapeutic potential. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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