Effect of Thyrotropin-Releasing Hormone and Its Synthetic Analogue Digipramine on Certain Indices of Hemostasis in vitro and in vivo
| Autor: | Golubeva Mg, M. E. Grigorjeva |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.medical_treatment Neuropeptide Thyrotropin-releasing hormone Biology General Biochemistry Genetics and Molecular Biology Endocrinology Coagulation In vivo Hemostasis Internal medicine Fibrinolysis medicine Nasal administration General Agricultural and Biological Sciences hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Biology Bulletin. 32:254-257 |
| ISSN: | 1608-3059 1062-3590 |
| DOI: | 10.1007/s10525-005-0098-y |
| Popis: | The effect of neuropeptide thyrotropin-releasing hormone (TRH) and its synthetic analogue digipramine on certain indices of blood coagulation and fibrinolysis were studied in vitro and in vivo. The peptides added to the pool of normal rat plasma at 10−10 to 10−3 M increased the procoagulant activity but had virtually no effect on fibrinolysis. Intravenous administration of TRH and digipramine increased the procoagulant activity of the blood and platelet aggregation but decreased fibrinolysis; digipramine had a more pronounced effect on the coagulation potential of the blood and a less pronounced effect on fibrinolytic indices as compared to TRH. Intranasal administration of the peptides did not change the pattern of their effect on indices of hemostasis although the effects became less pronounced. |
| Databáze: | OpenAIRE |
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