Three-day intravenous triple therapy is not effective for the eradication of Helicobacter pyloriinfection in patients with bleeding gastro-duodenal ulcer
| Autor: | P. Hergueta, O. Santos, J.M. Navarro, C. Martínez-Delgado, C. Montojo, Manuel Romero-Gómez, A. Garrido-Serrano |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Breath test
medicine.medical_specialty Hepatology biology medicine.diagnostic_test medicine.drug_class business.industry Gastroenterology Proton-pump inhibitor Rapid urease test Amoxicillin Helicobacter pylori biology.organism_classification Internal medicine Clarithromycin medicine Pharmacology (medical) business Omeprazole medicine.drug Antibacterial agent |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 18:1023-1029 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.2003.01763.x |
| Popis: | Summary Aim : To test the efficacy of an ultra-short intravenous triple therapy against Helicobacter pylori infection in patients with bleeding peptic ulcer against standard oral 1-week triple therapy in a randomised, double-blind prospective trial. Methods: Patients : (n = 75) with haemorrhagic peptic ulcer and H. pylori infection were randomised into: an Intravenous Group to receive omeprazole, clarithromycin and amoxicillin–clavulanic acid intravenously b.d. for 3 days followed by 7 days of oral omeprazole plus placebo of clarithromycin and amoxicillin; an Oral Group to receive intravenous omeprazole plus placebo of clarithromycin and amoxicillin–clavulanic acid followed by 7 days of oral omeprazole, clarithromycin and amoxicillin b.d. Gastric biopsies were obtained for urease test. A 13C-urea breath test was performed to check for H. pylori eradication. Results : Intention-to-treat eradication was 50% (19/38) in the Intravenous Group and 78% (29/37) in the Oral Group (odds ratio 3.63; 95% confidence interval 1.32–9.94; P |
| Databáze: | OpenAIRE |
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