Synthesis of the oxazole- and diene-containing C9–C23 fragment of the type a streptogramin antibiotics

Autor:	Javed Iqbal, Mikael Bergdahl, Gangloff Anthony R, Robert Hett, Timothy L. Friebe, Yinghui Wu, Paul Helquist
Rok vydání:	1993
Předmět:	Addition reaction Diene medicine.drug_class Fragment (computer graphics) Stereochemistry Organic Chemistry Antibiotics Streptogramin Biochemistry chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry Stereoselectivity Aldol condensation Oxazole
Zdroj:	Tetrahedron Letters. 34:7371-7374
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)60128-4
Popis:	The right-hand portion (3) of the type A streptogramin antibiotics was synthesized in non-racemic form through use of a Horner-Wadsworth-Emmons reaction for diene construction, an asymmetric aldol condensation, and a zinc-promoted oxazole addition reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3616314c54d07f1238ac8c108445e686 https://doi.org/10.1016/s0040-4039(00)60128-4 Zobrazit plný text záznamu