Cutting Edge: Intrinsic Programming of Thymic γδT Cells for Specific Peripheral Tissue Localization

Autor:	Yan Jin, Kavitha Narayan, David L. Wiest, Mingcan Xia, Joonsoo Kang, Yanming Wang, Christina M. Saylor, Na Xiong
Rok vydání:	2010
Předmět:	integumentary system First line T cell Immunology Biology Peripheral Cell biology medicine.anatomical_structure medicine Immunology and Allergy Process (anatomy) Organ Specificity γδt cells
Zdroj:	The Journal of Immunology. 185:7156-7160
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.1002781
Popis:	Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR–ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::36135576d308c0a9f78b64e328ec2b73 https://doi.org/10.4049/jimmunol.1002781 Zobrazit plný text záznamu