Diadenosine-5-phosphate exerts A1-Receptor-mediated proarrhythmic effects in rabbit atrial myocardium
| Autor: | Burkhard Sievers, D. Dirkmann, Rolf Borchard, M. van Bracht, M.W. Prull, Ingo Wickenbrock, H.-J. Trappe, Bodo Brandts |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
medicine.medical_specialty Voltage clamp medicine.medical_treatment Purinergic receptor Antiarrhythmic agent Biology Adenosine Adenosine A1 receptor Electrophysiology Endocrinology Internal medicine Muscarinic acetylcholine receptor cardiovascular system medicine Myocyte cardiovascular diseases medicine.drug |
| Zdroj: | British Journal of Pharmacology. 139:1265-1272 |
| ISSN: | 0007-1188 |
| DOI: | 10.1038/sj.bjp.0705361 |
| Popis: | Diadenosine polyphosphates have been described to be present in the myocardium and exert purinergic- and nonreceptor-mediated effects. Since the electrophysiological properties of atrial myocardium are effectively regulated by A1 receptors, we investigated the effect of diadenosine pentaphosphate (Ap5A) in rabbit myocardium. Parameters of supraventricular electrophysiology and atrial vulnerability were measured in Langendorff-perfused rabbit hearts. Muscarinic potassium current (IK(ACh/Ado)) and ATP-sensitive potassium current (IK(ATP)) were measured by using the whole-cell voltage clamp method. Ap5A prolonged the cycle length of spontaneously beating Langendorff perfused hearts from 225±14 (control) to 1823±400 ms (Ap5A 50 μM; n=6; P |
| Databáze: | OpenAIRE |
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