Effect of Prolonged Sodium Bromide Administration on the Fine Structure of Dendrites in the Superior Cervical Ganglion of Adult Rat
| Autor: | J.R. Wolff, W. Dames, Ferenc Joó |
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| Rok vydání: | 1979 |
| Předmět: |
Superior cervical ganglion
Anatomy Hyperpolarization (biology) Sympathetic ganglion law.invention Postsynaptic membrane Sodium bromide chemistry.chemical_compound medicine.anatomical_structure chemistry law medicine Biophysics Molecular mechanism sense organs Electron microscope Artificial cerebrospinal fluid |
| DOI: | 10.1016/s0079-6123(08)61298-4 |
| Popis: | Publisher Summary This chapter presents experiments to confirm whether sodium bromide, a substance known to produce stable hyperpolarization in sympathetic ganglion of frogs, is capable of modifying the properties of receptive surfaces of neurons in the superior cervical ganglion (SCG) of adult rat. Long-lasting sodium bromide microinfusion was provided into the superior cervical ganglion of adult rats. Ganglia from the experimental and control groups (infused with artificial cerebrospinal fluid) were processed for electron microscopy. Axons and synapsing terminals were frequently seen in the experimental as in control ganglia. After sodium bromide treatment, plastic changes were seen in dendrites, which were similar in their main characteristics to those described earlier with γ-aminobutyric acid (GABA). These consisted mostly of the formation of non-innervated postsynaptic membrane thickenings, accumulation of microvesicles, and changes in the shape of dendrites. The possible molecular mechanism of plastic change of dendrites is also discussed in the chapter. |
| Databáze: | OpenAIRE |
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