| Popis: |
A mild reduction method of C3-oximido-1,4-benzodiazepines to afford the C3-amino derivatives is described. The key step involves the formation of a carbamate oxime intermediate. The greater reactivity of the C3-(ethylaminocarbonyl)oximido-1,4-benzodiazepine towards hydrogenation, compared to the parent C3-oxime, enables the reduction to take place at. ambient temperature using palladium-on-carbon. The mild conditions are more suitable for sensitive amines such as 3,5-diamino-1,4-benzodiazepines |
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