Long-Acting, Injectable Antiretroviral Therapy for the Management of HIV Infection: An Update on a Potential Game-Changer
| Autor: | Anouk Amzel, Tom Minior, Linda M. Mobula, Christine Y Malati, Natella Rakhmanina, B. Ryan Phelps, Robert Ferris, Matt Barnhart |
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| Rok vydání: | 2015 |
| Předmět: |
Resource poor
medicine.medical_specialty business.industry Immunology Human immunodeficiency virus (HIV) virus diseases Hiv management Dermatology medicine.disease_cause Antiretroviral therapy Treatment failure Infectious Diseases ANTIRETROVIRAL AGENTS Long acting immune system diseases Virology medicine Intensive care medicine business Potential game health care economics and organizations |
| Zdroj: | Journal of AIDS & Clinical Research. |
| ISSN: | 2155-6113 |
| DOI: | 10.4172/2155-6113.1000466 |
| Popis: | The efficacy of daily oral antiretroviral (ARVs), even when combined with supplemental adherence strategies, remains limited by non-adherence. Resistance and treatment failure resulting from missed ARV doses continue to hamper efforts to curb the epidemic. This commentary argues that we must simplify ARV regimens even further, and highlights the potential for long-acting injectable (LAI) formulations to facilitate weekly, monthly, and multi-month ARV regimens in both resource rich and resource poor settings. We summarize the latest progress in LAI development and reflect on the potential of LAIs to revolutionize HIV management and define the next frontier of HIV medicine. |
| Databáze: | OpenAIRE |
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