CD4+ Monocyte Counts in Persons with HIV-1 Infection
| Autor: | Daniel R. Lucey, C A Butzin, R E Hensley, W W Ward, R. N. Boswell |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Sexually transmitted disease
medicine.diagnostic_test Monocyte virus diseases Biology medicine.disease Flow cytometry Infectious Diseases medicine.anatomical_structure Acquired immunodeficiency syndrome (AIDS) Antigen Immunopathology Immunology medicine Pharmacology (medical) Viral disease Immunodeficiency |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 4:24 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/00126334-199101000-00003 |
| Popis: | In this study, we asked whether there is a difference in the number of CD4+ and CD4- peripheral blood monocytes as CD4+ T cells decrease during HIV-mediated immunodeficiency. Monocytes and T cells from 90 HIV-positive and 43 HIV-negative persons were analyzed by flow cytometry. The 90 HIV-positive patients represented the entire spectrum of CD4+ T-cell counts. We report that as CD4+ T cells decrease, the number of CD4+ monocytes decrease in parallel. Moreover, significantly higher CD4+ monocyte counts were observed in persons with early stage HIV disease, i.e., greater than 800 CD4+ T cells/mm3, than in HIV-negative persons with greater than 800 CD4+ T cells/mm3. Potential implications of these findings are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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