Association between genetic variations at 8q24 and prostate cancer risk in Mexican Men
| Autor: | A. R. Aragón-Tovar, E. J. Macías-González, J. E. Torres-García, Katia Peñuelas-Urquides, M. B. Calao-Pérez, D. I. Ibarra-Pérez, M. Bermúdez de León, O. S. Frausto-Valdes, Laura Adiene González-Escalante, Beatriz Silva-Ramírez |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Urology Single-nucleotide polymorphism Locus (genetics) urologic and male genital diseases medicine.disease Genotype frequency Prostate cancer Internal medicine Genetic variation Genotype Medicine Benign prostatic hyperplasia (BPH) Allele business |
| Zdroj: | Prostate Cancer and Prostatic Diseases. 25:507-512 |
| ISSN: | 1476-5608 1365-7852 |
| DOI: | 10.1038/s41391-021-00461-x |
| Popis: | Variants of 8q24 locus have been associated with prostate cancer (PCa) susceptibility. This study aims to analyze the genetic basis of PCa susceptibility in Mexican men by analyzing SNPs in the 8q24 locus for the first time. A case-control study was performed in 875 men recruited from the Mexican Social Security Institute, 326 patients with PCa, and 549 non-PCa patients (88 with benign prostatic hyperplasia BPH and 461 healthy controls). The 8q24 locus SNPs: rs16901979, rs16983267, rs1447295, and rs7837328 were genotyped by allelic discrimination assays using TaqMan probes. Statistical analysis was performed using Epi Info statistical 7.0 and SNPstats softwares. All genotype frequencies were in Hardy-Weinberg Equilibrium. No differences were observed in genotype distribution between PCa and non-PCa patients for rs6983267. Under different inheritance models, the rs16901979, rs1447295, and rs7837328 SNPs were associated with PCa (OR = 2.8, 1.8, and 1.72, respectively; Pc |
| Databáze: | OpenAIRE |
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