Aberrant expression of CD5 in a B-lineage Acute Lymphoblastic Leukemia (ALL): a case report
| Autor: | Ni Ketut Puspa Sari, Ni Nyoman Mahartini, Ni Kadek Mulyantari, Anak Agung Ayu Lydia Prawita, Ni Komang Krisnawati, I Putu Yuda Prabawa, Sianny Herawati, Made Minarti Witarini Dewi, Ekarini Katharina Yunarti Nabu |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Intisari Sains Medis. 12:473-476 |
| ISSN: | 2503-3638 2089-9084 |
| DOI: | 10.15562/ism.v12i2.1011 |
| Popis: | Background: CD5 is expressed in several B-lymphocyte malignancies, including Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL), but CD5 positive B-cell lineage Acute Lymphoblastic Leukemia (ALL) is extremely rare. Aberrant T-cell antigen expression is associated with poor prognosis and is a useful marker to identify patients at increased risk. This case report aims to elaborate on the aberrant expression of CD5 in B-lineage ALL.Case Presentation: A 16-years-old male presented with a history of gum bleeding and abdominal pain of 7 days with associated fever, weakness and bone pain of 2-month duration. The bone marrow aspiration showed lymphoblast 30 % with the positive vacuole. In addition, the immunophenotyping test indicates for leukemia B-lineage with expression CD19, CD10, HLA-DR, CD 34, and there is the aberrant expression of CD5.Conclusion: Aberrant expression CD5 in cases of ALL B lineage is very rare. This can be associated with a poor prognosis. |
| Databáze: | OpenAIRE |
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