Patient survival on the dose escalation phase of the Oncolytic Polio/Rhinovirus Recombinant (PVSRIPO) against WHO grade IV malignant glioma (MG) clinical trial compared to historical controls
| Autor: | John H. Sampson, Denise Lally-Goss, Katherine B. Peters, Frances McSherry, Darell D. Bigner, Susan Boulton, Dina Randazzo, Allan H. Friedman, Matthias Gromeier, James E. Herndon, Gordana Vlahovic, Annick Desjardins, Stevie Threatt, Henry S. Friedman, Eric S. Lipp |
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| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.medical_specialty Chemotherapy Bevacizumab business.industry medicine.medical_treatment medicine.disease_cause Malignancy medicine.disease Gastroenterology Tumor antigen Oncolytic virus 03 medical and health sciences Titer 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Internal medicine Glioma medicine Rhinovirus business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 34:2061-2061 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2016.34.15_suppl.2061 |
| Popis: | 2061Background: The live attenuated oral (SABIN) serotype 1 poliovirus vaccine was modified to contain a heterologous internal ribosomal entry site stemming from human rhinovirus type 2, creating PVSRIPO. PVSRIPO recognizes CD155, an oncofetal cell adhesion molecule and tumor antigen widely expressed ectopically in malignancy. We report the survival results of the dose-finding portion evaluating PVSRIPO delivered intratumorally by convection-enhanced delivery (CED) compared to a historical control group of patients (pts) treated at Duke. Methods: Eligible pts on trial were adults with recurrent supratentorial WHO grade IV MG; solitary tumor 1-5cm in diameter; ≥ 4 weeks after chemotherapy, bevacizumab or study drug; adequate organ function; KPS ≥ 70%; and positive anti-polio titer. A historical group of adult recurrent WHO grade IV mg pts treated at Duke between 1/01/07-12/15/14 was retrospectively identified based on presence of a solitary tumor 1-5cm in diameter, KPS ≥ 70%, and absence of clinical declin... |
| Databáze: | OpenAIRE |
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