Further Evidence Supporting a Parent-of-Origin Effect in Psoriatic Disease
| Autor: | Arane Thavaneswaran, Art Petronis, Remy A. Pollock, Dafna D. Gladman, Proton Rahman, Vinod Chandran, Fawnda Pellett |
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| Rok vydání: | 2015 |
| Předmět: |
030203 arthritis & rheumatology
Proband 0303 health sciences medicine.medical_specialty business.industry Arthritis medicine.disease Logistic regression Dermatology 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine McNemar's test Rheumatology Psoriasis Internal medicine Statistical significance medicine Family history business 030304 developmental biology |
| Zdroj: | Arthritis Care & Research. 67:1586-1590 |
| ISSN: | 2151-464X |
| DOI: | 10.1002/acr.22625 |
| Popis: | Objective To further explore the “parent-of-origin” effect in a large cohort of well-phenotyped patients with cutaneous psoriasis without arthritis (PsC) and psoriatic arthritis (PsA). Methods Self-reported family history was obtained from PsA patients from Toronto and Newfoundland satisfying the Classification of Psoriatic Arthritis criteria, and PsC patients from Toronto, who were examined by a rheumatologist to exclude PsA. Proportions of probands with paternally and maternally transmitted psoriatic disease were compared by McNemar's and chi-square tests. Baseline clinical and genetic characteristics of probands with paternally and maternally transmitted disease were compared using logistic regression. Results A total of 849 probands reported a first-degree relative affected with psoriatic disease (PsC or PsA), of which 532 (63%) reported an affected parent. A significantly larger proportion of probands reported an affected father compared to an affected mother with psoriatic disease (289 [57%] versus 220 [43%], respectively; P = 0.003). This paternal transmission bias was evident in PsA (P = 0.006) and PsC probands, although it did not reach statistical significance in PsC probands (P = 0.20). Furthermore, the proportion of paternal PsC–proband PsA pairs (161 of 214 paternal transmissions [75%]) was significantly larger than maternal PsC–proband PsA pairs (103 of 161 maternal transmissions [64%]) (P = 0.02). Newfoundland probands with paternally transmitted disease had higher HLA–B*08 carriage (P = 0.04) and lower MICA–129Met carriage (P = 0.03). Males had higher HLA–B*38 carriage (P = 0.05) and a higher prevalence of nail lesions (P = 0.01). Conclusion We have provided further epidemiologic evidence of a paternal transmission bias in psoriatic disease. |
| Databáze: | OpenAIRE |
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