Adverse Effects of Virus-Specific T-Cell Therapy: An Integrative Review
| Autor: | Joyce E. Dains, Angela F. Bazzell, Heidi Z Simmons |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry T cell medicine.medical_treatment Disease Drug resistance medicine.disease Virus Targeted therapy 03 medical and health sciences Cytokine release syndrome 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Toxicity medicine Adverse effect business 030215 immunology |
| Zdroj: | Journal of the Advanced Practitioner in Oncology. 10 |
| ISSN: | 2150-0878 |
| DOI: | 10.6004/jadpro.2019.10.2.3 |
| Popis: | Allogeneic hematopoietic stem cell transplant (HSCT) remains the mainstay in treating many hematologic malignancies. T-cell-depleted grafts designed to reduce graft-vs.-host disease (GVHD) may be complicated by severe viral infections that increase morbidity and mortality. Despite the use of antiviral pharmacologic therapy, challenges in controlling viral infections include drug resistance and/or side-effect intolerability. Virus-specific T-cell (VST) therapy is a promising targeted therapy for treating severe or drug-refractory viral infections after HSCT. An integrative review was conducted to inform advanced practitioners of the adverse effects associated with VST. A total of 836 articles were identified using PubMed, Scopus, and CINAHL databases, with 7 included in this review. Studies reviewed indicate that the adverse effects associated with VST therapy are limited and generally treatable. These studies reported low rates of adverse events of mild to moderate severity, including acute, recurrent, chronic, and de novo GVHD; cytokine release syndrome; infusion toxicity; and other adverse events. No deaths were attributed to VSTs in these studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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