Encapsulated Lime Peel Essential Oil (Citrus hystrix) Into Chitosan Nanoparticle: New Entity to Enhanced Effectivity Against Propionilbacterium Acne in Vitro
| Autor: | Linda Julianti Wijayadi, Taty Rusliati Rusli |
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| Rok vydání: | 2020 |
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| Zdroj: | IOP Conference Series: Materials Science and Engineering. 852:012016 |
| ISSN: | 1757-899X 1757-8981 |
| DOI: | 10.1088/1757-899x/852/1/012016 |
| Popis: | Acne Vulgaris (AV) is a chronic inflammatory disease that affects 85% of the population at least once throughout their lives. The pathogenesis of AV including hypercolonization in pilosebaseous glands by P. acnes. Effective and efficient acne therapeutics including topical acne medications remain a crucial aspect of acne research. The lime peel essential oil contains triterpenoid steroid and has antibacterial effect against P. acnes. Chitosan is a natural material produced by deacetylyation of chitin from crustacean exoskeleton. Being biocompatible, biodegradable, and affordable, chitosan is widely explored in biomedical field as active agent or drug carrier. In this study, the lime peel essential oil was encapsulated into chitosan nanoparticle through ionotropic gelation technique to be formulated into topical acne cream preparation. The aim of this study was to evaluate and to compare the efficacy of encapsulated and non encapsulated lime peel essential oil into chitosan nanoparticle in inhibiting P. acnes. The inhibition zone of P. acnes which known as non-growth area after exposure to lime peel essential oil encapsulated into chitosan nanoparticle was calculated. The result showed chitosan nanoparticle formula led to an inhibitory zone of 20, 61 mm in diameter, while non-encapsulated formula only led to 10-20 mm. Result led to conclusion that chitosan nanoparticle encapsulation formulation led to improved P. acnes inhibitory activity of lime peel essential oil. |
| Databáze: | OpenAIRE |
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