Aryl and vinyl cyclopropanes through the in situ generation of B-cyclopropyl-9-BBN and its Suzuki–Miyaura coupling

Autor:	Ramon Huertas, Gisela Leon-Colon, John A. Soderquist
Rok vydání:	2000
Předmět:	In situ chemistry.chemical_compound chemistry Aqueous sodium hydroxide Aryl Organic Chemistry Drug Discovery chemistry.chemical_element Propargyl bromide Boron Biochemistry Medicinal chemistry Adduct
Zdroj:	Tetrahedron Letters. 41:4251-4255
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00605-5
Popis:	Dihydroboration of propargyl bromide with 9-BBN-H followed by treatment of the adduct with aqueous sodium hydroxide affords the hydroxy(cyclopropyl)borate complex (1), which undergoes efficient palladium-catalyzed cross-coupling to produce a variety of aryl and vinyl cyclopropanes (2) in good to excellent yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::35c6300efa88486ed18116323aa11d56 https://doi.org/10.1016/s0040-4039(00)00605-5 Zobrazit plný text záznamu Full Text from ScienceDirect