| Autor: |
Aswathy Ammothumkandy, Luis Corona, Kristine Ravina, Victoria Wolseley, Nora Jimenez, Michelle Armacost, Lina M. D’Orazio, Jeremy Nelson, Virginia Zuverza-Chavarria, Carol McCleary, George Nune, Laura Kalayjian, Darrin Lee, Brian Lee, Christianne Heck, Robert H. Chow, Jonathan J Russin, Charles Y. Liu, Jason A.D. Smith, Michael A. Bonaguidi |
| Rok vydání: |
2022 |
| Popis: |
Mesial temporal lobe epilepsy is a syndromic disorder presenting with seizures and cognitive comorbidities. The cellular mechanisms contributing to epilepsy progression are not well understood. Here we show that intelligence, verbal learning, and memory decline at a critical period when hippocampal neurogenesis becomes undetectable. Individual patient analysis revealed that the number of immature neurons, rather than total granule neurons, particularly benefit verbal learning. These results illustrate a functional role for adult human neurogenesis and reveal a therapeutic target accompanying cognitive decline. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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