| Popis: |
Background : Pyrethroid pesticide poisoning cases in developed and developing countries have a high incidence every year. One of the active substances in pyrethroid widely used is cypermethrin. The effects of cypermethrin intoxication on the kidneys, especially in humans, are little to be studied. This study aims to determine the difference in the histopathological image of the Wistar rat’s kidney. Method: The experimental research of the post-test only control group design involved 24 male Wistar rats divided into 4 groups randomly, the control (not given cypermethrin), treatments of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Cypermethrin are given orally for 14 days. After the rats were terminated, the kidney were processed to be paraffin-embedded tissues and stained with HE. Tubular injuries were examined using 400x magnification of light microscope and focused on closure of tubular lumen as well as proteinaceous cast inside the lumens. Results : The results of this study showed that the means of histopathological damage to the kidneys increased from control group to 500 mg/kgBW treatment group. Statistical analysis with One way ANOVA showed significant differences (p |
