26 The role of properdin in murine atherosclerosis
| Autor: | Cordula M. Stover, Tanja Steiner, Lorenza Francescut, Sheila E. Francis |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry nutritional and metabolic diseases food and beverages chemical and pharmacologic phenomena Complement system Lesion Immune system Endocrinology chemistry Internal medicine LDL receptor medicine Properdin lipids (amino acids peptides and proteins) medicine.symptom Cardiology and Cardiovascular Medicine business Glycoprotein Receptor Lipoprotein |
| Zdroj: | Heart. 97:e7-e7 |
| ISSN: | 1355-6037 |
| DOI: | 10.1136/heartjnl-2011-300920b.26 |
| Popis: | Background Atherosclerosis in humans and mice has inflammatory, immune and metabolic components. Mice lacking low-density lipoprotein receptor (LDLR(−/−)) may be protected from atherogenesis by some components of the complement system. The serum glycoprotein Properdin is a key amplifier of complement activation. The role of Properdin in atherosclerosis has not yet been studied. Methodology We crossed LDLR(−/−) mice with Properdin-knockout mice and examined atherosclerosis in LDLR(−/−) Properdin-knockout (LDLR(−/−)P-KO) mice compared with LDLR(−/−) Properdin-wildtype (LDLR(−/−)P-WT) fed either a low (LFD) or high-fat diet (HFD; Abdiets / The Netherlands) for 12 weeks. Results On LFD, there were no differences in body weight, atherosclerotic burden in aortae and lipid profiles between genotypes (LDLR(−/−)P-KO vs LDLR(−/−)P-WT) or genders. This was not the case in mice fed the HFD. On HFD, % lesion coverage in the aorta was greater in female LDLR(−/−)P-KO mice compared with males (5.06±0.71 % (f) vs 1.44±0.16 % (m), p Conclusion These data provide preliminary evidence that Properdin may be protective in HFD-induced atherosclerosis in female mice and the mechanism for this observation is currently under investigation. |
| Databáze: | OpenAIRE |
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