Autor:	Konstantin Karaghiosoff, Jörn Martens, Christina Hettstedt, Robert J. Mayer, Sarah Linert
Rok vydání:	2015
Předmět:	Reaction mechanism Trimethylsilyl 010405 organic chemistry Stereochemistry Quinoline Nuclear magnetic resonance spectroscopy Crystal structure 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Pyridine
Zdroj:	European Journal of Inorganic Chemistry. 2016:726-735
ISSN:	1099-0682 1434-1948
DOI:	10.1002/ejic.201501120
Popis:	The reaction of (chloromethyl)dichlorophosphine (1) with 2-[(trimethylsilyl)methyl] pyridine (6) and 2-[(trimethylsilyl) methyl] quinoline (12) in THF affords unsubstituted parent 2-phosphaindolizine (5) and [1,3]azaphospholo[1,5-a] quinoline (7). Multinuclear low-temperature NMR spectroscopy was used to investigate the reaction mechanism;a cascade of substitution and cyclization steps involving transient picolylphosphines and phosphorus heterocycles was identified. The molecular and crystal structures of two heterocyclic intermediates and of 7 were determined by single-crystal X-ray diffraction. Moreover, all intermediates and products were characterized by multinuclear H-1, C-13 and P-31 NMR spectroscopy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::35b382f0039359e65d2c069cfe5acb10 https://doi.org/10.1002/ejic.201501120 Zobrazit plný text záznamu Plný text