Autor: |
Ramesh Patnam, René Roy, Mathieu Neault, Denis Giguère, Juan M. Juarez‐Ruiz |
Rok vydání: |
2009 |
Předmět: |
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Zdroj: |
Tetrahedron Letters. 50:4254-4257 |
ISSN: |
0040-4039 |
Popis: |
A catalytic synthesis of novel 4-linked C -glycosyl coumarins was achieved using a domino Heck reaction/lactonization process. Methyl 3-glycosyl cinnamates were prepared from methyl 4-glycosyl-but-2-enoates using a panel of aryl iodides under Heck conditions. A direct application of this new methodology was made toward preliminary hemagglutination inhibition assays against galectins-1 and -3. C-Galactoside 30 had an IC 50 of 313 μM against galectin-1. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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