Catalytic synthesis of novel 4-C-glycosyl coumarins using a domino Heck reaction/lactonization process

Autor:	Ramesh Patnam, René Roy, Mathieu Neault, Denis Giguère, Juan M. Juarez‐Ruiz
Rok vydání:	2009
Předmět:	animal structures Chemistry Aryl Organic Chemistry Biochemistry Domino Catalysis carbohydrates (lipids) chemistry.chemical_compound Heck reaction Scientific method Drug Discovery Cinnamates Organic chemistry Glycosyl
Zdroj:	Tetrahedron Letters. 50:4254-4257
ISSN:	0040-4039
Popis:	A catalytic synthesis of novel 4-linked C -glycosyl coumarins was achieved using a domino Heck reaction/lactonization process. Methyl 3-glycosyl cinnamates were prepared from methyl 4-glycosyl-but-2-enoates using a panel of aryl iodides under Heck conditions. A direct application of this new methodology was made toward preliminary hemagglutination inhibition assays against galectins-1 and -3. C-Galactoside 30 had an IC 50 of 313 μM against galectin-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::35acbcf12cedf003083cdba3592bb1ce https://doi.org/10.1016/j.tetlet.2009.04.134 Zobrazit plný text záznamu Full Text from ScienceDirect