Pathophysiology of Cerebral Ischemia

Autor: Michael G. Hennerici, Günter Krämer, Werner Hacke, Herman J. Gelmers
Rok vydání: 1991
Předmět:
Zdroj: Cerebral Ischemia ISBN: 9783642755507
DOI: 10.1007/978-3-642-75548-4_2
Popis: The weight of the brain amounts to only 2% of total body weight, but it receives 15% of the cardiac output and uses 20% of the oxygen consumed by the body. The energy supply is provided almost exclusively by glucose metabolism. The substrate for this is stored in the brain in the form of glucose or glycogen and is sufficient to cover the energy requirements for only about 1 min. Consequently, there is a delicate equilibrium between oxygen and nutrient supply from the blood and the energy requirements of the brain. Disturbances in neurologic function appear after a few seconds of ischemia, although they are not necessarily persistent at first.
Databáze: OpenAIRE