Localization of Achrosomal Antigenicity in Guinea Pig Testes

Autor:	O. Vilar, R. E. Mancini, D. C. Bueno, M. Nemirovsky, O. W. Davidson
Rok vydání:	1962
Předmět:	Germinal epithelium Antigenicity Pathology medicine.medical_specialty Biology Sertoli cell General Biochemistry Genetics and Molecular Biology Guinea pig Multinucleate medicine.anatomical_structure Vacuolization Antigen medicine Germ cell
Zdroj:	Experimental Biology and Medicine. 111:435-438
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-111-27816
Popis:	Morphologic damage of the adult guinea pig testis can be induced by the single intracutaneous injection of homologous testes extract plus complete Freund adjuvants(1–3). The characteristic feature of this phenomenon is sloughing of the germinal epithelium so extensive as to result in complete aspermatogenesis. Vacuolization of spermatogonia, pycnosis of germ cell nuclei, appearance of multinucleated cells and cytoplasmic vacuolization of Sertoli cells have been related morphologic findings; no influence on the Leydig cells has been observed. That this reaction is due to an immunologic mechanism has been amply demonstrated. Various authors have reported the presence of circulating antibodies (1), delayed cutaneous hypersensitivity(1) and effectiveness of passive transfer by white cells from sensitized donors(4). Attempts have been made to characterize chemically the antigen responsible for the induced aspermatogenesis. Since the initial work of Freund(1) attention has been focused upon the carbohydrate ric...
Databáze:	OpenAIRE
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