| Autor: |
Christopher Hulme, Irini Akritopoulou-Zanze, Wei-Min Dai, Barbara Beck, Stuti Srivastava, Wei Wang, Kan Wang, Anna Czarna, Tad A. Holak, Lidio Meireles, Carlos Camacho, Balu Raghavan, Billy W. Day, Alexander Dömling, Chuanguang Qin, Ruijie Zhang, Qiuyu Wang, Jin Ren, Linqi Tian, Mikhail Nikulnikov, Mikhail Krasavin, Vladislav Parchinsky, Sergey Shkavrov, Konstantin Bukhryakov, Sergey Tsirulnikov, Ekaterina Bushkova, Cédric Kalinski, Volodymyr Kysil, Alexandre Ivachtchenko, Victor V. Potapov, Volodymyr M. Kysil, Nataliya A. Fetisova, Alexandr V. Nikitin, Alexandre V. Ivachtchenko, Alexey P. Ilyn, Dmitri V. Kravchenko, Olga Shilova, Alexey Ilyin, Alexandre M. Shkirando, Buchi Reddy Vaddula, Dalip Kumar, Shashwat Sharad, Urvashi Dube, Suman Kapur |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
MCR 2009 ISBN: 9781441972699 |
| Popis: |
This presentation will discuss approaches to enhance the rate of molecular probe discovery and close the growing knowledge gap between chemical and biological space created by recent advances in systems biology. As such, multi-component reactions are advocated as tools to build proprietary compound collections, founded on the central tenets of efficiency in medicinal chemistry: (1) the potential for increased “iterative speed” around the “hypothesis–synthesis–screening” loop and (2) reduced numbers of required iterations for expedited value chain progression. Front-loading collections, in this respect, have afforded several successful “bench-to-bedside” studies with no required intermediate “scaffold hopping.” Such examples may be viewed as the original “holy grail” of combinatorial chemistry, now enabled by the exponentially increasing MCR-derived “chemical diversity space” made accessible in recent years. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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