Synthesis of Rovafovir Etalafenamide (Part III): Evolution of the Synthetic Process to the Phosphonamidate Fragment

Autor:	Jeffrey A. O. Garber, Edmund Leung, Olga Lapina, Selcuk Calimsiz, Keshab Sarma, Jonah W. Curl, Guojun Yu, Andrew Anthony Martins, Bing Shi, Jaspal Phull, Bernard Kwong, Jinyu Shen, Andrea Ambrosi, Sankar Mohan, Mary Rosario, Huy V. Huynh, Li Wang, Lennie Lin, Dustin Bringley, Eric A. Standley, Teague M. McGinitie, Xueqing Wang, Ben Roberts
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Reverse-transcriptase inhibitor 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Human immunodeficiency virus (HIV) 010402 general chemistry medicine.disease_cause 01 natural sciences 0104 chemical sciences Part iii Fragment (logic) parasitic diseases medicine Nucleotide Physical and Theoretical Chemistry medicine.drug
Zdroj:	Organic Process Research & Development. 25:1247-1262
ISSN:	1520-586X 1083-6160
DOI:	10.1021/acs.oprd.0c00428
Popis:	Phosphonamidate 1 is a key fragment in the assembly of rovafovir etalafenamide, a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the treatment of HIV infe...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3585ed6f2b4c9d546264e8c3574d36f6 https://doi.org/10.1021/acs.oprd.0c00428 Zobrazit plný text záznamu