Formulation of inhalable beclomethasone dipropionate-mannitol composite particles through low-temperature supercritical assisted atomization
| Autor: | Liang-Jung Chien, Hsien-Tsung Wu, Hong-Ming Tsai, Tsung-Hsuan Li, Yao-Hsiang Chuang |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
General Chemical Engineering Composite number 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics 030226 pharmacology & pharmacy Supercritical fluid 03 medical and health sciences 0302 clinical medicine Chemical engineering Dry powder medicine Drug release Mannitol Physical and Theoretical Chemistry 0210 nano-technology Dissolution Aerosolization medicine.drug |
| Zdroj: | The Journal of Supercritical Fluids. 168:105095 |
| ISSN: | 0896-8446 |
| DOI: | 10.1016/j.supflu.2020.105095 |
| Popis: | Mannitol carrier and drug-carrier composite particles were produced via low-temperature supercritical assisted atomization (LTSAA). The enhanced aerosolization of the mannitol carrier particles with added L-leucine could be attributed to the formation of fine corrugated particles, which reduced the interparticle cohesion and led to better flowability of the mannitol carrier particles. A poorly water-soluble drug, beclomethasone dipropionate (BDP), and mannitol co-precipitated during LTSAA with the optimal addition of 9.1 mass % L-leucine. The in vitro aerosolization and dissolution experiments indicated that the fine particles fraction (FPF) of the drug-carrier composite particles was 3.4 times (FPF = 49.9 %) higher than that of the as-received BDP (FPF = 14.7 %) and the 63.2 % drug release time of the drug-carrier composite particles was 15.6 times faster than that of as-received BDP. This study suggests that the drug-carrier composites produced using LTSAA can be employed in the instant formulation of inhalable dry powder. |
| Databáze: | OpenAIRE |
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