| Popis: |
Background: The diagnosis of venous thromboembolism (VTE) during pregnancy is a challenging task. Due to its naturally high level during pregnancy, D-Dimer concentration is not reliable diagnostic. P-selectin is another diagnostic biomarker that can aid the diagnosis of VTE. In the present study, an attempt was made to determine the relationship between P-selectin and acute VTE in pregnant women and compare it’s predictive value with Wells criteria.Materials and methods: In this case-control study, 29 pregnant women with pulmonary thromboembolism (PTE), 33 pregnant women with deep vein thrombosis (DVT), and 32 matched healthy pregnant women were investigated. After obtaining informed written consent, 3 cc of venous blood sample was taken from each of the participants. The samples were then assessed for P-selectin and D-Dimer concentrations via the use of ELISA tests. Finally, statistical analyses were performed. Findings: Significant differences were observed between all of the groups under investigation in terms of both mean P-selectin and mean D-Dimer concentrations (PConclusion: The increase in P-selectin concentration during pregnancy is associated with high incidence of VTE. Compared with D-Dimer, P-selectin is a predictor of thrombosis, especially in patients with high clinical probability based on Wells score. |
