Synthesis and characterisation of a partially methylated dodecyl thiomaltotrioside derivative as a precursor of cyclodextrin analogue

Autor:	N Sakairi, Respati Tri Swasono, Bambang Purwono, Hesty Parbuntari
Rok vydání:	2019
Předmět:	chemistry.chemical_classification History chemistry.chemical_compound chemistry Cyclodextrin Combinatorial chemistry Derivative (chemistry) Computer Science Applications Education
Zdroj:	Journal of Physics: Conference Series. 1317:012032
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/1317/1/012032
Popis:	Due to the enermous roles of cyclodextrin combining with small organic molecules, more recent interests study about the manipulation of cyclodextrin structure giving better performance for any kinds of field but they presented long synthetis steps as producing the precursors. This study points out the synthesis of precursor of β-cyclodextrin analouges with maltotriose as raw materials giving the short synthesis steps. The product structures were analysed by Fourier Transform Infrared (FTIR) Specstroscopy,and characterised by 1H-, 13C- NMR, COSY NMR, and ESI Mass Spectroscopy. The result showed that O-acetylation reaction produced maltotriose derivative 1 (95%), thioglycosidation reaction produced maltotriose derivative 2 (54%), de-acetylation reaction produced maltotriose derivative 3 (97%), O-benzylidation reaction produced a mixture of maltotriose derivatives 4, O- methylation reaction produced maltotriose derivative 5 (46%) and de-benzylidation reaction produced maltotriose derivative 6 (85%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::354ef16010505b13083bd8cdfe6886b5 https://doi.org/10.1088/1742-6596/1317/1/012032 Zobrazit plný text záznamu