A new biosensor detection system to overcome the Debye screening effect: dialysis-silicon nanowire field effect transistor
| Autor: | Tong Wang, Zengyao Li, Jianxin Tao, Longchang Huang, Ye Zhang, Hang Chen, Xiaoqian Zhao, Renhui Shen, Haoze Shi, Zhong Xi, Hang Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Biophysics Pharmaceutical Science Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials symbols.namesake Drug Discovery Silicon nanowires Debye chemistry.chemical_classification Screening effect business.industry Biomolecule Organic Chemistry technology industry and agriculture General Medicine equipment and supplies 021001 nanoscience & nanotechnology 0104 chemical sciences Highly sensitive chemistry symbols Optoelectronics Field-effect transistor 0210 nano-technology Dialysis (biochemistry) business Biosensor |
| Zdroj: | International Journal of Nanomedicine. 14:2985-2993 |
| ISSN: | 1178-2013 |
| DOI: | 10.2147/ijn.s198734 |
| Popis: | Background: A silicon nanowire field effect transistor biosensor has four advantages in the detection of small biomolecules. It is mark-free, immediately responsive, highly sensitive, and specific. However, because of environments with a high salt concentration, the Debye screening effect has been a major issue in biological detection. Objective: To overcome Debye screening effect, realize the clinical application of silicon nanowire field effect transistor and verify its specificity and sensitivity. Materials and methods: The test solution was desalted by miniature blood dialyzer, and then the tumor markers were detected by silicon nanowire field effect transistor. Results: Tumor markers in serum were detected successfully and their sensitivity and specificity were verified. Conclusion: This method was found to effectively promote the development of semiconductor materials in biological solution detection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|