Synthesis and in vitro antibacterial activity of new semi-synthetic noviosylcoumarin antibiotics: chemical modification at the C-3′ ester
| Autor: | Yasutsugu Ueda, Joan Fung-Tomc, Julia M. Chuang, R. A. Partyka |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
biology
Chemistry medicine.drug_class Stereochemistry Organic Chemistry Clinical Biochemistry Antibiotics Pharmaceutical Science Chemical modification Biological activity biology.organism_classification Biochemistry Chemical synthesis Combinatorial chemistry In vitro mental disorders Drug Discovery medicine Molecular Medicine Antibacterial activity Molecular Biology Bacteria Antibacterial agent |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:1623-1628 |
| ISSN: | 0960-894X |
| Popis: | A synthetic procedure to introduce a variety of ester groups at the C-3′ position of the noviosylcoumarin antibiotics has been developed. Several new semi-synthetic noviosylcoumarins having unique ester groups at the C-3′ position by this method were prepared and in vitro antibacterial (anti-staphylococcal) activity was evaluated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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