Interaction of HULC polymorphisms with Helicobacter pylori infection plays a strong role for the prediction of gastric cancer risk
| Autor: | Han-xi Ding, Qian Xu, Zhi Lv, Ben-Gang Wang, Yuan Yuan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Helicobacter pylori infection HULC Multifactor dimensionality reduction business.industry Single-nucleotide polymorphism Genomics General Medicine Odds ratio 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Expression quantitative trait loci medicine business Gene |
| Zdroj: | Future Oncology. 16:1997-2006 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2020-0228 |
| Popis: | Aim: Gene–environment interactions have better efficacy in predicting cancer susceptibility than a single gene. Materials & methods: Eight tag single nucleotide polymorphisms encompassing the whole HULC gene were detected by KASP platform (LGC Genomics, Hoddesdon, UK) in 631 gastric cancer (GC) cases and 953 controls. Results: The HULC gene rs7770772 polymorphism could increase GC risk (recessive model: odds ratio = 1.95). The multifactor dimensionality reduction (MDR) analysis suggested that the 2D model HULC rs7770772– Helicobacter pylori had better effect on GC risk prediction (maximum testing accuracy = 0.7005). No significant result was observed in our experimental expression quantitative trait loci analysis. Conclusion: 2D model HULC rs7770772– H. pylori might have superior efficacy for GC risk than a single factor. |
| Databáze: | OpenAIRE |
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