| Popis: |
Publisher Summary This chapter examines the restoration of function to the denervated spinal cord after the implantation of embryonic 5-hydroxytryptamine (5HT) and substance P-containing raphe neurons. 12 to 14 months after the grafting procedure, 5HT-containing cell bodies are found in the clusters of raphe neurons implanted in the spinal cord. Although it is impossible to distinguish whether they reflect a change in survival rather than an alteration in transmitter phenotype, it is clear that there exist differences between the recoveries of mesencephalic raphe neurons and of medullary raphe cells after transplantation to the spinal cord. Approximately half the 5HT-immunoreactive (IR) cells from the embryonic medullary raphe store substance P after transplanting to the spinal cord, reflecting the transmitter complement of the neurons in situ in normal animals. In the medulla oblongata, some neurons also store thyrotropin-releasing hormone (TRH) and, likewise, these have been detected in medullary raphe tissue grafted to spinal cord. |
